Highly efficient chiral resolution of DL-arginine by cocrystal formation followed by recrystallization under preferential-enrichment conditions.
Chemistry
; 20(33): 10343-50, 2014 Aug 11.
Article
en En
| MEDLINE
| ID: mdl-25042834
ABSTRACT
An excellent chiral symmetry-breaking spontaneous enantiomeric resolution phenomenon, denoted preferential enrichment, was observed on recrystallization of the 11 cocrystal of dl-arginine and fumaric acid, which is classified as a racemic compound crystal with a high eutectic ee value (>95 %), under non-equilibrium crystallization conditions. On the basis of temperature-controlled video microscopy and in situ time-resolved solid-state (13) Câ
NMR spectroscopic studies on the crystallization process, a new mechanism of phase transition that can induce preferential enrichment is proposed.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Arginina
Idioma:
En
Año:
2014
Tipo del documento:
Article