Intestinal nuclear receptors in HDL cholesterol metabolism.
J Lipid Res
; 56(7): 1262-70, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-25070952
ABSTRACT
The intestine plays a pivotal role in cholesterol homeostasis by functioning as an absorptive and secretory organ in the reverse cholesterol transport pathway. Enterocytes control cholesterol absorption, apoAI synthesis, HDL biogenesis, and nonbiliary cholesterol fecal disposal. Thus, intestine-based therapeutic interventions may hold promise in the management of diseases driven by cholesterol overload. Lipid-sensing nuclear receptors (NRs) are highly expressed in the intestinal epithelium and regulate transcriptionally the handling of cholesterol by the enterocytes. Here, we discuss the NR regulation of cholesterol fluxes across the enterocytes with special emphasis on NR exploitation as a bona fide novel HDL-raising strategy.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Receptores Citoplasmáticos y Nucleares
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Mucosa Intestinal
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HDL-Colesterol
Límite:
Animals
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Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article