Prenylated indole diketopiperazines from the marine-derived fungus Aspergillus versicolor.
J Org Chem
; 79(17): 7895-904, 2014 Sep 05.
Article
en En
| MEDLINE
| ID: mdl-25089636
ABSTRACT
Seven new prenylated indole diketopiperazines, versicamides A-G (1-7) and a novel chemical derivative from 7, versicamide H (8), along with three known analogic diketopiperazines (9-11) were obtained from the marine-derived fungus Aspergillus versicolor HDN08-60. Their structures were determined by spectroscopic techniques, including 2D NMR, ECD calculations, and single-crystal X-ray diffraction analysis, together with the assistance of further chemical conversions. The cytotoxicities of 1-8 were tested against the HeLa, HCT-116, HL-60, and K562 cell lines, but only 8 exhibited moderate activity against HL-60 cells, with an IC50 value of 8.7 µM. Further investigation with target screening showed that 8 exhibited selective PTK inhibitory activities.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aspergillus
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Células HL-60
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Dicetopiperazinas
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Hongos
Límite:
Humans
Idioma:
En
Año:
2014
Tipo del documento:
Article