Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/&#945;-ketoglutarate-dependent dioxygenase.

Eustáquio, Alessandra S; Janso, Jeffrey E; Ratnayake, Anokha S; O'Donnell, Christopher J; Koehn, Frank E

Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase.

Eustáquio, Alessandra S; Janso, Jeffrey E; Ratnayake, Anokha S; O'Donnell, Christopher J; Koehn, Frank E.

Afiliación

Eustáquio AS; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT 06340 alessandra.eustaquio@pfizer.com.
Janso JE; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT 06340.
Ratnayake AS; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT 06340.
O'Donnell CJ; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT 06340.
Koehn FE; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT 06340.

Proc Natl Acad Sci U S A ; 111(33): E3376-85, 2014 Aug 19.

Article en En | MEDLINE | ID: mdl-25097259

Asunto(s)

Burkholderia/metabolismo; Dioxigenasas/metabolismo; Hierro/metabolismo; Biocatálisis; Burkholderia/enzimología; Datos de Secuencia Molecular

Palabras clave

bacteria; natural product; secondary metabolite; thailanstatin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Burkholderia / Dioxigenasas / Hierro Idioma: En Año: 2014 Tipo del documento: Article

Texto completo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Burkholderia / Dioxigenasas / Hierro Idioma: En Año: 2014 Tipo del documento: Article