Biotransformation of finasteride by Ocimum sanctum L., and tyrosinase inhibitory activity of transformed metabolites: experimental and computational insights.
Steroids
; 92: 20-4, 2014 Dec.
Article
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| MEDLINE
| ID: mdl-25159102
ABSTRACT
Transformation of Finasteride (I) by cell suspension cultures of Ocimum sanctum L. was investigated. Fermentation of compound (I) with O. sanctum afforded three oxidized derivatives, 16ß-hydroxyfinasteride (II), 11α-hydroxyfinasteride (III) and 15ß-hydroxyfinasteride (IV). Among these metabolites, compound (II) was a new metabolite. Compound (I) and its derivatives were studied for their tyrosinase inhibition assay. All test compounds exhibited significant activity compared to standard drug kojic acid, with compound IV being the most potent member with an IC50 of 1.87µM. Molecular docking revealed significant molecular interactions behind the potent tyrosinase inhibitory activity of the tested compounds.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Monofenol Monooxigenasa
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Finasterida
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Ocimum
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Inhibidores Enzimáticos
Idioma:
En
Año:
2014
Tipo del documento:
Article