Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
Cell
; 158(6): 1335-1347, 2014 Sep 11.
Article
en En
| MEDLINE
| ID: mdl-25201528
ABSTRACT
The apical dendrites of many neurons contain proximal and distal compartments that receive synaptic inputs from different brain regions. These compartments also contain distinct complements of ion channels that enable the differential processing of their respective synaptic inputs, making them functionally distinct. At present, the molecular mechanisms that specify dendritic compartments are not well understood. Here, we report that the extracellular matrix protein Reelin, acting through its downstream, intracellular Dab1 and Src family tyrosine kinase signaling cascade, is essential for establishing and maintaining the molecular identity of the distal dendritic compartment of cortical pyramidal neurons. We find that Reelin signaling is required for the striking enrichment of HCN1 and GIRK1 channels in the distal tuft dendrites of both hippocampal CA1 and neocortical layer 5 pyramidal neurons, where the channels actively filter inputs targeted to these dendritic domains.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Serina Endopeptidasas
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Moléculas de Adhesión Celular Neuronal
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Proteínas de la Matriz Extracelular
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Dendritas
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Proteínas del Tejido Nervioso
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Neuronas
Límite:
Animals
Idioma:
En
Año:
2014
Tipo del documento:
Article