Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.
Bioorg Med Chem Lett
; 24(21): 5059-62, 2014 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-25266785
ABSTRACT
Methicillin-resistant Staphylococcus aureus pyruvate kinase (MRSA PK) has recently been identified as a target for development of novel antibacterial agents. Testing a series of 1,2-bis(3-indolyl)ethanes against MRSA PK has led to the discovery of a potent inhibitor that is selective over human isoforms.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piruvato Quinasa
/
Inhibidores Enzimáticos
/
Etano
/
Antibacterianos
Límite:
Humans
Idioma:
En
Año:
2014
Tipo del documento:
Article