Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma.
J Pathol
; 235(3): 456-65, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25294670
ABSTRACT
Undifferentiated nasopharyngeal carcinoma (NPC) is a highly metastatic disease that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we have investigated the contribution of lysophosphatidic acid (LPA) signalling to the pathogenesis of NPC. Here we demonstrate two distinct functional roles for LPA in NPC. First, we show that LPA enhances the migration of NPC cells and second, that it can inhibit the activity of EBV-specific cytotoxic T cells. Focusing on the first of these phenotypes, we show that one of the LPA receptors, LPA receptor 5 (LPAR5), is down-regulated in primary NPC tissues and that this down-regulation promotes the LPA-induced migration of NPC cell lines. Furthermore, we found that EBV infection or ectopic expression of the EBV-encoded LMP2A was sufficient to down-regulate LPAR5 in NPC cell lines. Our data point to a central role for EBV in mediating the oncogenic effects of LPA in NPC and identify LPA signalling as a potential therapeutic target in this disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Lisofosfolípidos
/
Transducción de Señal
/
Regulación hacia Abajo
/
Regulación Neoplásica de la Expresión Génica
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Neoplasias Nasofaríngeas
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Infecciones por Virus de Epstein-Barr
/
Receptores del Ácido Lisofosfatídico
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2015
Tipo del documento:
Article