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From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine.
Petrelli, Riccardo; Meli, Maria; Vita, Patrizia; Torquati, Ilaria; Ferro, Arianna; Vodnala, Munender; D'Alessandro, Natale; Tolomeo, Manlio; Del Bello, Fabio; Kusumanchi, Praveen; Franchetti, Palmarisa; Grifantini, Mario; Jayaram, Hiremagalur N; Hofer, Anders; Cappellacci, Loredana.
Afiliación
  • Petrelli R; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
  • Meli M; Dipartimento di Scienze per la Promozione della Salute e Materno-Infantile-Sezione di Farmacologia, Università di Palermo, 90127 Palermo, Italy.
  • Vita P; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
  • Torquati I; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
  • Ferro A; Dipartimento di Scienze per la Promozione della Salute e Materno-Infantile-Sezione di Farmacologia, Università di Palermo, 90127 Palermo, Italy.
  • Vodnala M; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
  • D'Alessandro N; Dipartimento di Scienze per la Promozione della Salute e Materno-Infantile-Sezione di Farmacologia, Università di Palermo, 90127 Palermo, Italy.
  • Tolomeo M; Centro Interdipartimentale di Ricerca in Oncologia Clinica, Policlinico 'P. Giaccone', Università di Palermo, 90127 Palermo, Italy.
  • Del Bello F; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
  • Kusumanchi P; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and Richard Roudebush VA Medical Center, Indianapolis, IN 46202, USA.
  • Franchetti P; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
  • Grifantini M; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
  • Jayaram HN; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and Richard Roudebush VA Medical Center, Indianapolis, IN 46202, USA.
  • Hofer A; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
  • Cappellacci L; School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy. Electronic address: loredana.cappellacci@unicam.it.
Bioorg Med Chem Lett ; 24(22): 5304-9, 2014 Nov 15.
Article en En | MEDLINE | ID: mdl-25304896
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ribonucleótido Reductasas / Adenosina / Ácido Valproico / Inhibidores Enzimáticos Límite: Humans Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ribonucleótido Reductasas / Adenosina / Ácido Valproico / Inhibidores Enzimáticos Límite: Humans Idioma: En Año: 2014 Tipo del documento: Article