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The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models.
Ravi, Dashnamoorthy; Bhalla, Savita; Gartenhaus, Ronald B; Crombie, Jennifer; Kandela, Irawati; Sharma, Jaya; Mazar, Andrew; Evens, Andrew M.
Afiliación
  • Ravi D; Molecular Oncology Research Institute and Division of Hematology Oncology, Tufts Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.
  • Bhalla S; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Gartenhaus RB; Marlene and Stewart Greenebaum Cancer Center, Department of Medicine, University of Maryland, Baltimore, Maryland.
  • Crombie J; Brigham and Women's Hospital, Boston, Massachusetts.
  • Kandela I; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois.
  • Sharma J; Molecular Oncology Research Institute and Division of Hematology Oncology, Tufts Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.
  • Mazar A; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois. Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois.
  • Evens AM; Molecular Oncology Research Institute and Division of Hematology Oncology, Tufts Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts. AEvens@tuftsmedicalcenter.org.
Clin Cancer Res ; 20(23): 6023-33, 2014 Dec 01.
Article en En | MEDLINE | ID: mdl-25316819
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arsenicales / Enfermedad de Hodgkin / Linfoma de Células T / Apoptosis / Proteínas Quinasas Activadas por Mitógenos / Proteína Tirosina Fosfatasa no Receptora Tipo 6 / Glutatión Límite: Animals / Humans Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arsenicales / Enfermedad de Hodgkin / Linfoma de Células T / Apoptosis / Proteínas Quinasas Activadas por Mitógenos / Proteína Tirosina Fosfatasa no Receptora Tipo 6 / Glutatión Límite: Animals / Humans Idioma: En Año: 2014 Tipo del documento: Article