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Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection.
Kato, Maiko; Tsuji-Kawahara, Sachiyo; Kawasaki, Yuri; Kinoshita, Saori; Chikaishi, Tomomi; Takamura, Shiki; Fujisawa, Makoto; Kawada, Akira; Miyazawa, Masaaki.
Afiliación
  • Kato M; Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan Department of Dermatology, Kinki University Faculty of Medicine, Osaka, Japan.
  • Tsuji-Kawahara S; Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
  • Kawasaki Y; Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
  • Kinoshita S; Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
  • Chikaishi T; Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan Unmet Medical Needs Pharma, Inc., Yokohama, Japan.
  • Takamura S; Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
  • Fujisawa M; Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
  • Kawada A; Department of Dermatology, Kinki University Faculty of Medicine, Osaka, Japan.
  • Miyazawa M; Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan masaaki@med.kindai.ac.jp.
J Virol ; 89(2): 1468-73, 2015 Jan 15.
Article en En | MEDLINE | ID: mdl-25378499
ABSTRACT
Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4+ T cells.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones Tumorales por Virus / Leucemia Experimental / Infecciones por Retroviridae / Hipermutación Somática de Inmunoglobulina / Anticuerpos Neutralizantes / Virus de la Leucemia Murina de Friend / Anticuerpos Antivirales Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones Tumorales por Virus / Leucemia Experimental / Infecciones por Retroviridae / Hipermutación Somática de Inmunoglobulina / Anticuerpos Neutralizantes / Virus de la Leucemia Murina de Friend / Anticuerpos Antivirales Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article