Effects of antihistamines on the function of human &#945;7-nicotinic acetylcholine receptors.

Sadek, Bassem; Khanian, Seyedeh Soha; Ashoor, Abrar; Prytkova, Tatiana; Ghattas, Mohammad A; Atatreh, Noor; Nurulain, Syed M; Yang, Keun-Hang Susan; Howarth, Frank Christopher; Oz, Murat

Effects of antihistamines on the function of human α7-nicotinic acetylcholine receptors.

Sadek, Bassem; Khanian, Seyedeh Soha; Ashoor, Abrar; Prytkova, Tatiana; Ghattas, Mohammad A; Atatreh, Noor; Nurulain, Syed M; Yang, Keun-Hang Susan; Howarth, Frank Christopher; Oz, Murat.

Afiliación

Sadek B; Laboratory of Functional Lipidomics, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Abu Dhabi, Al Ain, United Arab Emirates.
Khanian SS; Laboratory of Functional Lipidomics, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Abu Dhabi, Al Ain, United Arab Emirates.
Ashoor A; Laboratory of Functional Lipidomics, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Abu Dhabi, Al Ain, United Arab Emirates.
Prytkova T; Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, CA 92866, USA.
Ghattas MA; College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates.
Atatreh N; College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates.
Nurulain SM; Laboratory of Functional Lipidomics, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Abu Dhabi, Al Ain, United Arab Emirates.
Yang KH; Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, CA 92866, USA.
Howarth FC; Department of Physiology, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
Oz M; Laboratory of Functional Lipidomics, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Abu Dhabi, Al Ain, United Arab Emirates. Electronic address: Murat_Oz@uaeu.ac.ae.

Eur J Pharmacol ; 746: 308-16, 2015 Jan 05.

Article en En | MEDLINE | ID: mdl-25445036

Asunto(s)

Antagonistas de los Receptores Histamínicos H1/farmacología; Modelos Moleculares; Proteínas del Tejido Nervioso/antagonistas & inhibidores; Pirilamina/farmacología; Receptor Nicotínico de Acetilcolina alfa 7/antagonistas & inhibidores; Regulación Alostérica; Animales; Sitios de Unión; Células Cultivadas; Antagonistas de los Receptores Histamínicos H1/química; Antagonistas de los Receptores Histamínicos H1/metabolismo; Antagonistas de los Receptores H2 de la Histamina/química; Antagonistas de los Receptores H2 de la Histamina/metabolismo; Antagonistas de los Receptores H2 de la Histamina/farmacología; Antagonistas de los Receptores Histamínicos H3/química; Antagonistas de los Receptores Histamínicos H3/metabolismo; Antagonistas de los Receptores Histamínicos H3/farmacología; Humanos; Ketamina/química; Ketamina/metabolismo; Ketamina/farmacología; Cinética; Conformación Molecular; Simulación del Acoplamiento Molecular; Proteínas del Tejido Nervioso/genética; Proteínas del Tejido Nervioso/metabolismo; Oocitos/citología; Oocitos/efectos de los fármacos; Oocitos/metabolismo; Estructura Terciaria de Proteína; Pirilamina/química; Pirilamina/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Xenopus laevis; Receptor Nicotínico de Acetilcolina alfa 7/genética; Receptor Nicotínico de Acetilcolina alfa 7/metabolismo

Palabras clave

Antihistamine; Nicotinic acetylcholine receptor; Pyrilamine; Xenopus oocyte

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirilamina / Modelos Moleculares / Receptor Nicotínico de Acetilcolina alfa 7 / Antagonistas de los Receptores Histamínicos H1 / Proteínas del Tejido Nervioso Idioma: En Año: 2015 Tipo del documento: Article

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