Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors.

Naik, Maruti; Raichurkar, Anandkumar; Bandodkar, Balachandra S; Varun, Begur V; Bhat, Shantika; Kalkhambkar, Rajesh; Murugan, Kannan; Menon, Rani; Bhat, Jyothi; Paul, Beena; Iyer, Harini; Hussein, Syeed; Tucker, Julie A; Vogtherr, Martin; Embrey, Kevin J; McMiken, Helen; Prasad, Swati; Gill, Adrian; Ugarkar, Bheemarao G; Venkatraman, Janani; Read, Jon; Panda, Manoranjan

Naik, Maruti; Raichurkar, Anandkumar; Bandodkar, Balachandra S; Varun, Begur V; Bhat, Shantika; Kalkhambkar, Rajesh; Murugan, Kannan; Menon, Rani; Bhat, Jyothi; Paul, Beena; Iyer, Harini; Hussein, Syeed; Tucker, Julie A; Vogtherr, Martin; Embrey, Kevin J; McMiken, Helen; Prasad, Swati; Gill, Adrian; Ugarkar, Bheemarao G; Venkatraman, Janani; Read, Jon; Panda, Manoranjan.

Afiliación

Naik M; Department of Chemistry, and Department of Bioscience, Innovative Medicines Infection, AstraZeneca India Pvt. Ltd. , Bellary Road, Hebbal, Bangalore, Karnataka 560024, India.

J Med Chem ; 58(2): 753-66, 2015 Jan 22.

Article en En | MEDLINE | ID: mdl-25486447

Asunto(s)

Inhibidores Enzimáticos/síntesis química; Mycobacterium tuberculosis/efectos de los fármacos; Timidilato Sintasa/antagonistas & inhibidores; Sitios de Unión; Descubrimiento de Drogas; Inhibidores Enzimáticos/farmacología; Ensayos Analíticos de Alto Rendimiento; Humanos; Espectroscopía de Resonancia Magnética; Mycobacterium tuberculosis/enzimología; Relación Estructura-Actividad; Timidilato Sintasa/química

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Timidilato Sintasa / Inhibidores Enzimáticos / Mycobacterium tuberculosis Límite: Humans Idioma: En Año: 2015 Tipo del documento: Article

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