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Comorbidity and performance status as independent prognostic factors in patients with head and neck squamous cell carcinoma.
Wang, Jennifer R; Habbous, Steven; Espin-Garcia, Osvaldo; Chen, Duoduo; Huang, Shao Hui; Simpson, Colleen; Xu, Wei; Liu, Fei-Fei; Brown, Dale H; Gilbert, Ralph W; Gullane, Patrick J; Irish, Jonathan C; Goldstein, David P; Liu, Geoffrey.
Afiliación
  • Wang JR; Department of Otolaryngology-Head and Neck Surgery, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Habbous S; Ontario Cancer Institute, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Espin-Garcia O; Ontario Cancer Institute, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Chen D; Ontario Cancer Institute, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Huang SH; Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Simpson C; Department of Otolaryngology-Head and Neck Surgery, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Xu W; Ontario Cancer Institute, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Liu FF; Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Brown DH; Department of Otolaryngology-Head and Neck Surgery, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Gilbert RW; Department of Otolaryngology-Head and Neck Surgery, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Gullane PJ; Department of Otolaryngology-Head and Neck Surgery, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Irish JC; Department of Otolaryngology-Head and Neck Surgery, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Goldstein DP; Department of Otolaryngology-Head and Neck Surgery, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Liu G; Ontario Cancer Institute, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Head Neck ; 38(5): 736-42, 2016 May.
Article en En | MEDLINE | ID: mdl-25521753
ABSTRACT

BACKGROUND:

The purpose of this study was to evaluate the individual and combined relationship of comorbidity and performance status (PS) on head and neck squamous cell carcinoma (HNSCC) survival.

METHODS:

Six hundred patients with HNSCC were prospectively recruited. Comorbidity and PS were measured using the Charlson Comorbidity Index (CCI) and the Eastern Cooperative Oncology Group (ECOG) Scale. Outcomes were overall survival (OS) and cancer-specific survival (CSS).

RESULTS:

A total of 48.3% of the patients had at least 1 comorbidity, and 42.3% had impaired PS at baseline. There was no correlation between CCI and ECOG (Spearman's ρ = 0.033; p = .42). In multivariate analysis, CCI score was significantly associated with OS (p = .01). ECOG was not associated with OS, but seems to act as an effect modifier in the association between comorbidity and OS. CCI and ECOG were not associated with CSS.

CONCLUSION:

CCI and ECOG scores both provide prognostic information in predicting OS in HNSCC, but a significant association with CSS was not observed.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2016 Tipo del documento: Article