Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine.
Parasite Immunol
; 37(2): 92-6, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25545116
ABSTRACT
The effect of Ixodes ricinus tick saliva on the production of various cytokines and chemokines by mouse splenocytes was tested by a cytokine array. We demonstrated a strong upregulation of three chemokines, monocyte chemoattractant protein-1 (MCP-1), thymus-derived chemotactic agent 3 (TCA-3) and macrophage inflammatory protein 2 (MIP-2). MCP-1 could be induced by tick saliva itself. While TCA-3 and MIP-2 are engaged in Th2 polarization of the host immune response associated with tick feeding, MCP-1 may act as a histamine release factor, increasing blood flow into the feeding lesion thus facilitating tick engorgement in the late, rapid feeding phase.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Quimiocina CCL2
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Ixodes
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Quimiocina CCL1
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Quimiocina CXCL2
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article