High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients.
J Med Microbiol
; 64(Pt 3): 243-247, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25587081
ABSTRACT
Previous work on the subclones within Escherichia coli ST131 predominantly involved isolates from Western countries. This study assessed the prevalence and antimicrobial resistance attributed to this clonal group. A total of 340 consecutive, non-duplicated urinary E. coli isolates originating from four clinical laboratories in Hong Kong in 2013 were tested. ST131 prevalence among the total isolates was 18.5â% (63/340) and was higher among inpatient isolates (23.0â%) than outpatient isolates (11.8â%, P<0.001), and higher among isolates from patients aged ≥65 years than from patients aged 18-50 years and 51-64 years (25.4 vs 3.4 and 4.0â%, respectively, P<0.001). Of the 63 ST131 isolates, 43 (68.3â%) isolates belonged to the H30 subclone, whereas the remaining isolates belonged to H41 (nâ=â17), H54 (nâ=â2) and H22 (nâ=â1). All H30 isolates were ciprofloxacin-resistant, of which 18.6â% (8/43) belonged to the H30-Rx subclone. Twenty-six (41.3â%) ST131 isolates were ESBL-producers, of which 19 had blaCTX-M-14 (12 non-H30-Rx, two H30-Rx and five H41), six had blaCTX-M-15 (five non-H30-Rx and one H30-Rx) and one was blaCTX-M-negative (H30). In conclusion, ST131 accounts for a large share of the antimicrobial-resistant E. coli isolates from geriatric patients. Unlike previous reports, ESBL-producing ST131 strains mainly belonged to non-H30-Rx rather than the H30-Rx subclone, with blaCTX-M-14 as the dominant enzyme type.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Urinarias
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Farmacorresistencia Bacteriana
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Escherichia coli
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Infecciones por Escherichia coli
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Antiinfecciosos
Tipo de estudio:
Prevalence_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2015
Tipo del documento:
Article