Long-lasting physiological effects of bath applied N-methyl-D-aspartate.
Brain Res
; 476(1): 170-3, 1989 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-2563332
ABSTRACT
The present experiments describe a long-lasting form of potentiation induced in field CA1 of rat hippocampal slices by bath application of N-methyl-D-aspartate (NMDA), in association with low magnesium concentrations, glycine and spermine. The potentiation effect consisted of a 50% increase in slope of field potentials and was stable for at least 80 min post treatment. It was not accompanied by detectable changes in antidromic responses and was completely blocked by an antagonist of NMDA receptor. The possible relationship of pharmacologically induced potentiation to long-term potentiation (LTP) is discussed.
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Banco de datos:
MEDLINE
Asunto principal:
Ácido Aspártico
/
Hipocampo
Límite:
Animals
Idioma:
En
Año:
1989
Tipo del documento:
Article