Dasatinib-induced pulmonary hypertension in acute lymphoblastic leukemia: case report.
Turk Kardiyol Dern Ars
; 43(1): 78-81, 2015 Jan.
Article
en En
| MEDLINE
| ID: mdl-25655855
ABSTRACT
Pulmonary hypertension (PHT) is a pathological condition determined as an increase in mean pulmonary arterial pressure ≥25 mmHg. Pulmonary arterial hypertension (PAH) is precapillary PHT and a life-threatening disease group which consists of different etiologies with the same pathological and clinical findings, and which is characterized by elevated pulmonary vascular resistance. Dasatinib is a dual Src/Abl kinase inhibitor associated with higher affinity for BCR/ABL kinase than imatinib, and is used in the treatment of chronic myelocytic leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia (ALL). We describe a case with ALL, in whom dasatinib treatment induced PAH, and who recovered with bosentan treatment.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pirimidinas
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Tiazoles
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Hipertensión Pulmonar
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Antineoplásicos
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Año:
2015
Tipo del documento:
Article