Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor.
Curr Drug Targets
; 17(6): 640-50, 2016.
Article
en En
| MEDLINE
| ID: mdl-25777272
ABSTRACT
CD6, one of the first antigens to be identified on T cells, is a membrane glycoprotein that physically associates with the antigen receptor complex. Because of this, its main function seems to involve the modulation of TCR-mediated signaling pathways. However, growing evidence indicates that this ancient and conserved scavenger-like receptor may also play a role as pattern recognition receptor (PRR), similar to other members of the scavenger receptor cysteine rich superfamily (SRCR-SF). Here, we discuss the functional interactions of CD6 with microbe- and damage-associated signals and the potential use of soluble forms of CD6 in the therapeutic treatment of bacterial infections, in particular multi-drug resistant bacterial strains. Importantly, microbe recognition by CD6 may also have functional consequences on T cell activation and differentiation, which remain to be explored.
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Banco de datos:
MEDLINE
Asunto principal:
Receptores de Antígenos de Linfocitos T
/
Linfocitos T
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Antígenos de Diferenciación de Linfocitos T
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Antígenos CD
/
Receptores Depuradores
Límite:
Animals
/
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article