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APOE ε4 Genotype and the Risk for Subjective Cognitive Impairment in Elderly Persons.
Krell-Roesch, Janina; Woodruff, Bryan K; Acosta, Jazmin I; Locke, Dona E; Hentz, Joseph G; Stonnington, Cynthia M; Stokin, Gorazd B; Nagle, Chelsea; Michel, Bernard F; Sambuchi, Nathalie; Caselli, Richard J; Geda, Yonas E.
Afiliación
  • Krell-Roesch J; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Woodruff BK; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Acosta JI; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Locke DE; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Hentz JG; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Stonnington CM; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Stokin GB; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Nagle C; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Michel BF; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Sambuchi N; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Caselli RJ; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
  • Geda YE; From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
J Neuropsychiatry Clin Neurosci ; 27(4): 322-5, 2015.
Article en En | MEDLINE | ID: mdl-25803305
ABSTRACT
The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E ε4 (APOE ε4) allele (cases) and APOE ε4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used multivariable logistic regression analyses to compute odds ratios and 95% confidence intervals adjusted for age, sex, education, and marital status. Data were available on 114 participants (83 women; 47 APOE ε4 carriers; mean age, 69 years). The risk for SCI was significantly higher among cases than controls, particularly for those 70 years of age and older. These findings should be considered preliminary until confirmed by a prospective cohort study.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apolipoproteínas E / Envejecimiento / Trastornos del Conocimiento / Predisposición Genética a la Enfermedad Tipo de estudio: Etiology_studies / Observational_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apolipoproteínas E / Envejecimiento / Trastornos del Conocimiento / Predisposición Genética a la Enfermedad Tipo de estudio: Etiology_studies / Observational_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article