Activation of latent metastases in the lung after resection of a metastatic lymph node in a lymph node metastasis mouse model.
Biochem Biophys Res Commun
; 460(3): 543-8, 2015 May 08.
Article
en En
| MEDLINE
| ID: mdl-25824032
ABSTRACT
Iatrogenic induction of regional and distant cancer metastases is a risk associated with clinical resection of tumor-positive sentinel lymph nodes. However, there have been no studies of this risk in a mouse model of cancer metastasis. Here, we report that resection of a tumor-bearing subiliac lymph node (SiLN) enhanced lung metastasis in a mouse model of lymph node metastasis. Bioluminescence imaging revealed that metastatic tumor cells in the secondary lymph node continued to grow after resection of the SiLN, and that the probability of metastasis to the lungs was increased when the interval between SiLN inoculation and resection was reduced. Futhermore, histological analysis demonstrated that latents in the lung were stimulated to grow after resection of the SiLN. Fluorescence imaging indicated that the route of tumor cell dissemination from SiLN to the lung was the venous system located over the SiLN. We speculate that our mouse model will be useful for studying the mechanisms of tumor cell latency, with a view to improving the detection and treatment of latent metastases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pulmonares
/
Escisión del Ganglio Linfático
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Metástasis Linfática
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article