Synergistic streptococcal phage &#955;SA2 and B30 endolysins kill streptococci in cow milk and in a mouse model of mastitis.

Schmelcher, Mathias; Powell, Anne M; Camp, Mary J; Pohl, Calvin S; Donovan, David M

Synergistic streptococcal phage λSA2 and B30 endolysins kill streptococci in cow milk and in a mouse model of mastitis.

Schmelcher, Mathias; Powell, Anne M; Camp, Mary J; Pohl, Calvin S; Donovan, David M.

Afiliación

Schmelcher M; Animal Biosciences and Biotechnology Laboratory, North East Area, Agricultural Research Service, U.S. Department of Agriculture, 10300 Baltimore Ave, Beltsville, MD, 20705, USA. mathias.schmelcher@hest.ethz.ch.
Powell AM; Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, LFV B18, 8092, Zurich, Switzerland. mathias.schmelcher@hest.ethz.ch.
Camp MJ; Animal Biosciences and Biotechnology Laboratory, North East Area, Agricultural Research Service, U.S. Department of Agriculture, 10300 Baltimore Ave, Beltsville, MD, 20705, USA.
Pohl CS; Statistics Group, Office of the North East Area Director, Agricultural Research Service, U.S. Department of Agriculture, 10300 Baltimore Ave, Beltsville, MD, 20705, USA.
Donovan DM; Animal Biosciences and Biotechnology Laboratory, North East Area, Agricultural Research Service, U.S. Department of Agriculture, 10300 Baltimore Ave, Beltsville, MD, 20705, USA.

Appl Microbiol Biotechnol ; 99(20): 8475-86, 2015 Oct.

Article en En | MEDLINE | ID: mdl-25895090

Asunto(s)

Endopeptidasas/metabolismo; Mastitis/tratamiento farmacológico; Viabilidad Microbiana/efectos de los fármacos; Leche/microbiología; Infecciones Estreptocócicas/tratamiento farmacológico; Fagos de Streptococcus/enzimología; Streptococcus/efectos de los fármacos; Animales; Carga Bacteriana; Calcio/metabolismo; Bovinos; Modelos Animales de Enfermedad; Sinergismo Farmacológico; Endopeptidasas/aislamiento & purificación; Femenino; Humanos; Concentración de Iones de Hidrógeno; Glándulas Mamarias Humanas/microbiología; Mastitis/microbiología; Ratones; Concentración Osmolar; Infecciones Estreptocócicas/microbiología; Resultado del Tratamiento

Palabras clave

Antimicrobial; Bacteriophage; Endolysin; Mastitis; Peptidoglycan hydrolase; Streptococcus

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Endopeptidasas / Infecciones Estreptocócicas / Streptococcus / Fagos de Streptococcus / Leche / Viabilidad Microbiana / Mastitis Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2015 Tipo del documento: Article

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