Enhancement of Inducible Nitric Oxide Synthase Activity by Low Molecular Weight Peptides Derived from Protamine: A Potential Therapy for Chronic Rhinosinusitis.

Balijepalli, Anant S; Comstock, Adam T; Wang, Xuewei; Jensen, Gary C; Hershenson, Marc B; Zacharek, Mark A; Sajjan, Umadevi S; Meyerhoff, Mark E

Balijepalli, Anant S; Comstock, Adam T; Wang, Xuewei; Jensen, Gary C; Hershenson, Marc B; Zacharek, Mark A; Sajjan, Umadevi S; Meyerhoff, Mark E.

Afiliación

Balijepalli AS; Department of Chemistry, University of Michigan, 930 North University, Ann Arbor, Michigan 48109, United States.
Comstock AT; Department of Pediatrics and Communicable Diseases, University of Michigan Health System, 1150 West Medical Center, Ann Arbor, Michigan 48109, United States.
Wang X; Department of Chemistry, University of Michigan, 930 North University, Ann Arbor, Michigan 48109, United States.
Jensen GC; Department of Chemistry, University of Michigan, 930 North University, Ann Arbor, Michigan 48109, United States.
Hershenson MB; Department of Pediatrics and Communicable Diseases, University of Michigan Health System, 1150 West Medical Center, Ann Arbor, Michigan 48109, United States.
Zacharek MA; §Department of Otolaryngology, University of Michigan Health System, 1500 East Medical Center, Ann Arbor, Michigan 48109, United States.
Sajjan US; Department of Pediatrics and Communicable Diseases, University of Michigan Health System, 1150 West Medical Center, Ann Arbor, Michigan 48109, United States.
Meyerhoff ME; Department of Chemistry, University of Michigan, 930 North University, Ann Arbor, Michigan 48109, United States.

Mol Pharm ; 12(7): 2396-405, 2015 Jul 06.

Article en En | MEDLINE | ID: mdl-25978582

Asunto(s)

Óxido Nítrico Sintasa de Tipo II/metabolismo; Péptidos/uso terapéutico; Protaminas/uso terapéutico; Rinitis Alérgica/tratamiento farmacológico; Animales; Arginasa/metabolismo; Arginina/metabolismo; Línea Celular; Cisteína/metabolismo; Células Epiteliales/efectos de los fármacos; Células Epiteliales/metabolismo; Macrófagos/efectos de los fármacos; Macrófagos/metabolismo; Ratones; Peso Molecular; Óxido Nítrico/metabolismo; Nitritos/metabolismo; Rinitis Alérgica/metabolismo

Palabras clave

arginase; cell-penetrating peptides; chronic rhinosinusitis; cystic fibrosis; iNOS; nitric oxide; protamine; s-boronoethyl-l-cysteine

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos / Protaminas / Óxido Nítrico Sintasa de Tipo II / Rinitis Alérgica Límite: Animals Idioma: En Año: 2015 Tipo del documento: Article

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