Normal Taste Acceptance and Preference of PANX1 Knockout Mice.
Chem Senses
; 40(7): 453-9, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-25987548
ABSTRACT
Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Gusto
/
Conexinas
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Article