Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance.

Schmidt, Susanne; Bohn-Wippert, Kathrin; Schlattmann, Peter; Zell, Roland; Sauerbrei, Andreas

Schmidt, Susanne; Bohn-Wippert, Kathrin; Schlattmann, Peter; Zell, Roland; Sauerbrei, Andreas.

Afiliación

Schmidt S; Institute of Virology and Antiviral Therapy, German Consulting Laboratory for HSV and VZV, Jena University Hospital, Friedrich-Schiller University, Jena, Germany.
Bohn-Wippert K; Institute of Virology and Antiviral Therapy, German Consulting Laboratory for HSV and VZV, Jena University Hospital, Friedrich-Schiller University, Jena, Germany.
Schlattmann P; Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, Friedrich-Schiller University, Jena, Germany.
Zell R; Institute of Virology and Antiviral Therapy, German Consulting Laboratory for HSV and VZV, Jena University Hospital, Friedrich-Schiller University, Jena, Germany.
Sauerbrei A; Institute of Virology and Antiviral Therapy, German Consulting Laboratory for HSV and VZV, Jena University Hospital, Friedrich-Schiller University, Jena, Germany Andreas.Sauerbrei@med.uni-jena.de.

Antimicrob Agents Chemother ; 59(8): 4938-45, 2015 Aug.

Article en En | MEDLINE | ID: mdl-26055375

Asunto(s)

ADN Polimerasa Dirigida por ADN/genética; Farmacorresistencia Viral/genética; Herpesvirus Humano 1/genética; Timidina Quinasa/genética; Aciclovir/uso terapéutico; Adolescente; Adulto; Anciano; Anciano de 80 o más Años; Antivirales/uso terapéutico; Niño; Preescolar; Femenino; Foscarnet/uso terapéutico; Genotipo; Herpes Simple/tratamiento farmacológico; Herpes Simple/virología; Herpesvirus Humano 1/efectos de los fármacos; Humanos; Lactante; Recién Nacido; Masculino; Persona de Mediana Edad; Mutación/genética; Polimorfismo Genético/genética; Estudios Retrospectivos; Análisis de Secuencia de ADN/métodos; Proteínas Virales/genética; Adulto Joven

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Timidina Quinasa / Herpesvirus Humano 1 / Farmacorresistencia Viral / ADN Polimerasa Dirigida por ADN Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Año: 2015 Tipo del documento: Article

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