Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.

Balasubramani, Anand; Larjo, Antti; Bassein, Jed A; Chang, Xing; Hastie, Ryan B; Togher, Susan M; Lähdesmäki, Harri; Rao, Anjana

Balasubramani, Anand; Larjo, Antti; Bassein, Jed A; Chang, Xing; Hastie, Ryan B; Togher, Susan M; Lähdesmäki, Harri; Rao, Anjana.

Afiliación

Balasubramani A; 1] Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA [2] Sanford Consortium for Regenerative Medicine, La Jolla, California 92037, USA.
Larjo A; Department of Information and Computer Science, Aalto University School of Science, Aalto FI-00076, Finland.
Bassein JA; 1] Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA [2] Sanford Consortium for Regenerative Medicine, La Jolla, California 92037, USA.
Chang X; 1] Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA [2] Sanford Consortium for Regenerative Medicine, La Jolla, California 92037, USA.
Hastie RB; Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA.
Togher SM; Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA.
Lähdesmäki H; Department of Information and Computer Science, Aalto University School of Science, Aalto FI-00076, Finland.
Rao A; 1] Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA [2] Sanford Consortium for Regenerative Medicine, La Jolla, California 92037, USA [3] Department of Pharmacology, University of California, San Diego, Ca

Nat Commun ; 6: 7307, 2015 Jun 22.

Article en En | MEDLINE | ID: mdl-26095772

Asunto(s)

Células Madre Hematopoyéticas/metabolismo; Histonas/metabolismo; Proteínas Represoras/genética; Proteínas Supresoras de Tumor/metabolismo; Ubiquitina Tiolesterasa/metabolismo; Animales; Células de la Médula Ósea; Diferenciación Celular/genética; Craneosinostosis/genética; Células HEK293; Células Madre Hematopoyéticas/citología; Humanos; Discapacidad Intelectual/genética; Leucemia Mieloide/genética; Mastocitos/citología; Mastocitos/metabolismo; Ratones; Ratones Endogámicos C57BL; Mutación; Regiones Promotoras Genéticas; Proteínas Represoras/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Represoras / Células Madre Hematopoyéticas / Histonas / Proteínas Supresoras de Tumor / Ubiquitina Tiolesterasa Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article

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