Chronic neutrophilic leukaemia and plasma cell-related neutrophilic leukaemoid reactions.
Br J Haematol
; 171(3): 400-10, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26218186
ABSTRACT
Many cases reported as 'chronic neutrophilic leukaemia' have had an associated plasma cell neoplasm. Recent evidence suggests that the great majority of such cases represent a neutrophilic leukaemoid reaction to the underlying multiple myeloma or monoclonal gammopathy of undetermined significance. We have analysed all accessible reported cases to clarify the likely diagnosis and to ascertain whether toxic granulation, Döhle bodies and an increased neutrophil alkaline phosphatase score were useful in making a distinction between chronic neutrophilic leukaemia and a neutrophilic leukaemoid reaction. We established that all these changes occur in both conditions. Toxic granulation and Döhle bodies are more consistently present in leukaemoid reactions but also occur quite frequently in chronic neutrophilic leukaemia. The neutrophil alkaline phosphatase score is increased in both conditions and is of no value in making a distinction.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Gammopatía Monoclonal de Relevancia Indeterminada
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Leucemia Neutrofílica Crónica
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Leucemia Mieloide Aguda
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Degranulación de la Célula
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Neoplasias Primarias Secundarias
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Mieloma Múltiple
Tipo de estudio:
Diagnostic_studies
Límite:
Female
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Humans
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Male
Idioma:
En
Año:
2015
Tipo del documento:
Article