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Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity.
Yin, Yiyuan; Djakovic, Stevan; Marsters, Scot; Tien, Janet; Peng, Jing; Tremayne, Jarrod; Lee, Genee; Neve, Richard M; Wu, Yan; Merchant, Mark; Ashkenazi, Avi; Carter, Paul J.
Afiliación
  • Yin Y; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California.
  • Djakovic S; Department of Cancer Immunology, Genentech, Inc., South San Francisco, California.
  • Marsters S; Department of Cancer Immunology, Genentech, Inc., South San Francisco, California.
  • Tien J; Department of Translational Oncology, Genentech, Inc., South San Francisco, California.
  • Peng J; Department of Translational Oncology, Genentech, Inc., South San Francisco, California.
  • Tremayne J; Department of Translational Oncology, Genentech, Inc., South San Francisco, California.
  • Lee G; Department of Molecular Oncology, Genentech, Inc., South San Francisco, California.
  • Neve RM; Department of Molecular Oncology, Genentech, Inc., South San Francisco, California.
  • Wu Y; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California.
  • Merchant M; Department of Translational Oncology, Genentech, Inc., South San Francisco, California.
  • Ashkenazi A; Department of Cancer Immunology, Genentech, Inc., South San Francisco, California. pjc@gene.com aa@gene.com.
  • Carter PJ; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California. pjc@gene.com aa@gene.com.
Mol Cancer Ther ; 14(10): 2270-8, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26269606
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos / Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos / Anticuerpos Monoclonales / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos / Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos / Anticuerpos Monoclonales / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2015 Tipo del documento: Article