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Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study.
Issa, Jean-Pierre J; Roboz, Gail; Rizzieri, David; Jabbour, Elias; Stock, Wendy; O'Connell, Casey; Yee, Karen; Tibes, Raoul; Griffiths, Elizabeth A; Walsh, Katherine; Daver, Naval; Chung, Woonbok; Naim, Sue; Taverna, Pietro; Oganesian, Aram; Hao, Yong; Lowder, James N; Azab, Mohammad; Kantarjian, Hagop.
Afiliación
  • Issa JJ; Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, USA; Cancer Epigenetics Program, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, USA. Electronic address: jpissa@temple.edu.
  • Roboz G; Weill Cornell Medical College and New York Presbyterian Hospital, Division of Hematology and Oncology, New York, NY, USA.
  • Rizzieri D; Duke University Medical Center, Durham, NC, USA.
  • Jabbour E; University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX, USA.
  • Stock W; University of Chicago, Chicago, IL, USA.
  • O'Connell C; Jane Anne Nohl Division of Hematology Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Yee K; Princess Margaret Cancer Centre, Toronto, ON, Canada.
  • Tibes R; Mayo Clinic Arizona, Division of Hematology and Medical Oncology, Scottsdale, AZ, USA.
  • Griffiths EA; Roswell Park Cancer Institute, Buffalo, NY, USA.
  • Walsh K; Ohio State University, James Cancer Hospital, Wexner Medical Center, Columbus, OH, USA.
  • Daver N; University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX, USA.
  • Chung W; Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, USA.
  • Naim S; Astex Pharmaceuticals, Pleasanton, CA, USA.
  • Taverna P; Astex Pharmaceuticals, Pleasanton, CA, USA.
  • Oganesian A; Astex Pharmaceuticals, Pleasanton, CA, USA.
  • Hao Y; Astex Pharmaceuticals, Pleasanton, CA, USA.
  • Lowder JN; Astex Pharmaceuticals, Pleasanton, CA, USA.
  • Azab M; Astex Pharmaceuticals, Pleasanton, CA, USA.
  • Kantarjian H; University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX, USA.
Lancet Oncol ; 16(9): 1099-1110, 2015 Sep.
Article en En | MEDLINE | ID: mdl-26296954
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azacitidina / Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Relación Dosis-Respuesta a Droga Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azacitidina / Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Relación Dosis-Respuesta a Droga Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article