The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study.

Siam, Laila; Bleckmann, Annalen; Chaung, Han-Ning; Mohr, Alexander; Klemm, Florian; Barrantes-Freer, Alonso; Blazquez, Raquel; Wolff, Hendrik A; Lüke, Florian; Rohde, Veit; Stadelmann, Christine; Pukrop, Tobias

Siam, Laila; Bleckmann, Annalen; Chaung, Han-Ning; Mohr, Alexander; Klemm, Florian; Barrantes-Freer, Alonso; Blazquez, Raquel; Wolff, Hendrik A; Lüke, Florian; Rohde, Veit; Stadelmann, Christine; Pukrop, Tobias.

Afiliación

Siam L; Department of Neurosurgery, University Medical Center, Göttingen, Germany.
Bleckmann A; Department of Hematology and Medical Oncology, University Medical Center, Göttingen, Germany.
Chaung HN; Department of Medical Statistics, University Medical Center, Göttingen, Germany.
Mohr A; Department of Hematology and Medical Oncology, University Medical Center, Göttingen, Germany.
Klemm F; Department of Neuroradiology, University Medical Center, Göttingen, Germany.
Barrantes-Freer A; Department of Hematology and Medical Oncology, University Medical Center, Göttingen, Germany.
Blazquez R; Institute of Neuropathology, University Medical Center, Göttingen, Germany.
Wolff HA; Department of Hematology and Medical Oncology, University Medical Center, Göttingen, Germany.
Lüke F; Department of Radiotherapy and Radiation Oncology, University Medical Center, Göttingen, Germany.
Rohde V; Department of Internal Medicine III, Hematology and Medical Oncology, University Hospital Regensburg, Regensburg, Germany.
Stadelmann C; Department of Neurosurgery, University Medical Center, Göttingen, Germany.
Pukrop T; Institute of Neuropathology, University Medical Center, Göttingen, Germany.

Oncotarget ; 6(30): 29254-67, 2015 Oct 06.

Article en En | MEDLINE | ID: mdl-26299612

Asunto(s)

Neoplasias Encefálicas/secundario; Encéfalo/patología; Neoplasias de la Mama/patología; Carcinoma de Pulmón de Células no Pequeñas/secundario; Movimiento Celular; Neoplasias Pulmonares/patología; Anciano; Astrocitos/patología; Biomarcadores de Tumor/metabolismo; Biopsia; Encéfalo/metabolismo; Encéfalo/cirugía; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/mortalidad; Neoplasias Encefálicas/cirugía; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/mortalidad; Carcinoma de Pulmón de Células no Pequeñas/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/mortalidad; Proliferación Celular; Técnicas de Cocultivo; Femenino; Humanos; Estimación de Kaplan-Meier; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/mortalidad; Células MCF-7; Masculino; Persona de Mediana Edad; Neoplasia Residual; Neuroglía/patología; Modelos de Riesgos Proporcionales; Estudios Prospectivos; Factores de Riesgo; Factores de Tiempo; Resultado del Tratamiento

Palabras clave

astrocytes; brain metastasis; glial-pseudo capsule; metastatic infiltration; organ-specific defense

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Neoplasias de la Mama / Movimiento Celular / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2015 Tipo del documento: Article

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