Synthesis, Characterization, and Nitrogenase-Relevant Reactions of an Iron Sulfide Complex with a Bridging Hydride.
J Am Chem Soc
; 137(41): 13220-3, 2015 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-26457740
ABSTRACT
The FeMoco of nitrogenase is an iron-sulfur cluster with exceptional bond-reducing abilities. ENDOR studies have suggested that E4, the state that binds and reduces N2, contains bridging hydrides as part of the active-site iron-sulfide cluster. However, there are no examples of any isolable iron-sulfide cluster with a hydride, which would test the feasibility of such a species. Here, we describe a diiron sulfide hydride complex that is prepared using a mild method involving C-S cleavage of added thiolate. Its reactions with nitrogenase substrates show that the hydride can act as a base or nucleophile and that reduction can cause the iron atoms to bind N2. These results add experimental support to hydride-based pathways for nitrogenase.
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1
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Ferrosos
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Hidrógeno
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Nitrogenasa
Idioma:
En
Año:
2015
Tipo del documento:
Article