Recent Advances in Drug Discovery from South African Marine Invertebrates.
Mar Drugs
; 13(10): 6366-83, 2015 Oct 14.
Article
en En
| MEDLINE
| ID: mdl-26473891
ABSTRACT
Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm Cephalodiscus gilchristi, the ascidian Lissoclinum sp. and the sponge Topsentia pachastrelloides, are presented. Recent reports of the bioactivity and synthesis of the anti-cancer secondary metabolites cephalostatin and mandelalides (from C. gilchristi and Lissoclinum sp., respectively) and various analogues are presented. The threat of drug-resistant pathogens, e.g., methicillin-resistant Staphylococcus aureus (MRSA), is assuming greater global significance, and medicinal chemistry strategies to exploit the potent MRSA PK inhibition, first revealed by two marine secondary metabolites, cis-3,4-dihydrohamacanthin B and bromodeoxytopsentin from T. pachastrelloides, are compared.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Poliquetos
/
Poríferos
/
Urocordados
/
Descubrimiento de Drogas
Límite:
Animals
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Año:
2015
Tipo del documento:
Article