A physiologically based pharmacokinetic model to predict the pharmacokinetics of highly protein-bound drugs and the impact of errors in plasma protein binding.

Ye, Min; Nagar, Swati; Korzekwa, Ken

Ye, Min; Nagar, Swati; Korzekwa, Ken.

Afiliación

Ye M; Department of Pharmaceutical Science, Temple University School of Pharmacy, Philadelphia, PA, 19140, USA.
Nagar S; Department of Pharmaceutical Science, Temple University School of Pharmacy, Philadelphia, PA, 19140, USA.
Korzekwa K; Department of Pharmaceutical Science, Temple University School of Pharmacy, Philadelphia, PA, 19140, USA.

Biopharm Drug Dispos ; 37(3): 123-41, 2016 Apr.

Article en En | MEDLINE | ID: mdl-26531057

Asunto(s)

Proteínas Sanguíneas/metabolismo; Modelos Biológicos; Preparaciones Farmacéuticas/metabolismo; Humanos; Tasa de Depuración Metabólica; Unión Proteica; Distribución Tisular

Palabras clave

distribution volume; hepatic metabolism; physiologically based pharmacokinetic (PBPK) modeling; protein binding

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Proteínas Sanguíneas / Modelos Biológicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google