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Renal Blood Oxygenation Level-dependent Imaging in Longitudinal Follow-up of Donated and Remaining Kidneys.
Seif, Maryam; Eisenberger, Ute; Binser, Tobias; Thoeny, Harriet C; Krauer, Fabienne; Rusch, Aurelia; Boesch, Chris; Vogt, Bruno; Vermathen, Peter.
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  • Seif M; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
  • Eisenberger U; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
  • Binser T; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
  • Thoeny HC; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
  • Krauer F; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
  • Rusch A; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
  • Boesch C; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
  • Vogt B; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
  • Vermathen P; From the Departments of Radiology and Clinical Research, University of Bern, AMSM (DKF-DIPR), Pavilion 52A Inselspital, PO Box 35, CH-3010 Bern, Switzerland (M.S., T.B., F.K., A.R., C.B., P.V.); Department of Nephrology, University Hospital Essen-Duisburg, Essen, Germany (U.E.); Department of Radiol
Radiology ; 279(3): 795-804, 2016 Jun.
Article en En | MEDLINE | ID: mdl-26744926
ABSTRACT
Purpose To determine renal oxygenation changes associated with uninephrectomy and transplantation in both native donor kidneys and transplanted kidneys by using blood oxygenation level-dependent (BOLD) MR imaging. Materials and Methods The study protocol was approved by the local ethics committee. Thirteen healthy kidney donors and their corresponding recipients underwent kidney BOLD MR imaging with a 3-T imager. Written informed consent was obtained from each subject. BOLD MR imaging was performed in donors before uninephrectomy and in donors and recipients 8 days, 3 months, and 12 months after transplantation. R2* values, which are inversely related to tissue partial pressure of oxygen, were determined in the cortex and medulla. Longitudinal R2* changes were statistically analyzed by using repeated measures one-way analysis of variance with post hoc pair-wise comparisons. Results R2* values in the remaining kidneys significantly decreased early after uninephrectomy in both the medulla and cortex (P < .003), from 28.9 sec(-1) ± 2.3 to 26.4 sec(-1) ± 2.5 in the medulla and from 18.3 sec(-1) ± 1.5 to 16.3 sec(-1) ± 1.0 in the cortex, indicating increased oxygen content. In donors, R2* remained significantly decreased in both the medulla and cortex at 3 (P < .01) and 12 (P < .01) months. In transplanted kidneys, R2* remained stable during the first year after transplantation, with no significant change. Among donors, cortical R2* was found to be negatively correlated with estimated glomerular filtration rate (R = -0.47, P < .001). Conclusion The results suggest that BOLD MR imaging may potentially be used to monitor renal functional changes in both remaining and corresponding transplanted kidneys. (©) RSNA, 2016.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Imagen por Resonancia Magnética / Trasplante de Riñón / Riñón Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Imagen por Resonancia Magnética / Trasplante de Riñón / Riñón Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2016 Tipo del documento: Article