Cardiac MR elastography of the mouse: Initial results.
Magn Reson Med
; 76(6): 1879-1886, 2016 12.
Article
en En
| MEDLINE
| ID: mdl-26749052
ABSTRACT
PURPOSE:
Many cardiovascular diseases are associated with abnormal function of myocardial contractility or dilatability, which is related to elasticity changes of the myocardium over the cardiac cycle. The mouse is a common animal model in studies of the progression of various cardiomyopathies. We introduce a novel noninvasive approach using microscopic scale MR elastography (MRE) to measure the myocardium stiffness change during the cardiac cycle on a mouse model.METHODS:
A harmonic mechanical wave of 400 Hz was introduced into the mouse body. An electrocardiograph-gated and respiratory-gated fractional encoding cine-MRE pulse sequence was applied to encode the resulting oscillatory motion on a short-axis slice of the heart. Five healthy mice (age range, 3-13.5 mo) were examined. The weighted summation effective stiffness of the left ventricle wall during the cardiac cycle was estimated.RESULTS:
The ratio of stiffness at end diastole and end systole was 0.5-0.67. Additionally, variation in shear wave amplitude in the left ventricle wall throughout the cardiac cycle was measured and found to correlate with estimates of stiffness variation.CONCLUSION:
This study demonstrates the feasibility of implementing cardiac MRE on a mouse model. Magn Reson Med 761879-1886, 2016. © 2016 International Society for Magnetic Resonance in Medicine.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Función Ventricular Izquierda
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Imagen por Resonancia Cinemagnética
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Diagnóstico por Imagen de Elasticidad
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Técnicas de Imagen Cardíaca
Tipo de estudio:
Diagnostic_studies
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Evaluation_studies
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Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article