Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent.
Molecules
; 21(2): 140, 2016 Jan 26.
Article
en En
| MEDLINE
| ID: mdl-26821007
ABSTRACT
Miracle fruit (Synsepalum dulcificum) belongs to the Sapotaceae family. It can change flavors on taste buds, transforming acidic tastes to sweet. We evaluated various miracle fruit extracts, including water, butanol, ethyl acetate (EA), and hexane fractions, to determine its antioxidant effects. These extracts isolated from miracle fruit exerted potential for reduction of uric acid and inhibited xanthine oxidase activity in vitro and in monosodiumurate (MSU)-treated RAW264.7 macrophages. Moreover, we also found that the butanol extracts of miracle fruit attenuated oxonic acid potassium salt-induced hyperuricaemia in ICR mice by lowering serum uric acid levels and activating hepatic xanthine oxidase. These effects were equal to those of allopurinol, suggesting that the butanol extract of miracle fruit could be developed as a novel anti-hyperuricaemia agent or health food.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
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Synsepalum
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Hiperuricemia
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Butanoles
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Antioxidantes
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article