Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.

Wojcik, John; Lamontanara, Allan Joaquim; Grabe, Grzegorz; Koide, Akiko; Akin, Louesa; Gerig, Barbara; Hantschel, Oliver; Koide, Shohei

Wojcik, John; Lamontanara, Allan Joaquim; Grabe, Grzegorz; Koide, Akiko; Akin, Louesa; Gerig, Barbara; Hantschel, Oliver; Koide, Shohei.

Afiliación

Wojcik J; From the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637.
Lamontanara AJ; Swiss Institute for Experimental Cancer Research, School of Life Sciences, École polytechnique fédérale de Lausanne, 1015 Lausanne, Switzerland, and.
Grabe G; From the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland.
Koide A; From the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637.
Akin L; From the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637.
Gerig B; Swiss Institute for Experimental Cancer Research, School of Life Sciences, École polytechnique fédérale de Lausanne, 1015 Lausanne, Switzerland, and.
Hantschel O; Swiss Institute for Experimental Cancer Research, School of Life Sciences, École polytechnique fédérale de Lausanne, 1015 Lausanne, Switzerland, and oliver.hantschel@epfl.ch.
Koide S; From the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, Shohei.Koide@nyumc.org.

J Biol Chem ; 291(16): 8836-47, 2016 Apr 15.

Article en En | MEDLINE | ID: mdl-26912659

Asunto(s)

Anticuerpos Monoclonales de Origen Murino/química; Proteínas de Fusión bcr-abl/antagonistas & inhibidores; Proteínas de Fusión bcr-abl/química; Regulación Alostérica/efectos de los fármacos; Regulación Alostérica/inmunología; Anticuerpos Monoclonales de Origen Murino/inmunología; Anticuerpos Monoclonales de Origen Murino/farmacología; Línea Celular Tumoral; Proteínas de Fusión bcr-abl/inmunología; Proteínas de Fusión bcr-abl/metabolismo; Humanos; Dominios Homologos src

Palabras clave

ABL tyrosine kinase; FN3; PPI inhibitor; Src homology 2 domain (SH2 domain); enzyme inhibitor; protein engineering; protein-protein interaction; x-ray crystallography

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de Fusión bcr-abl / Anticuerpos Monoclonales de Origen Murino Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article

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