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Acquisition of Broad-Spectrum Cephalosporin Resistance Leading to Colistin Resistance in Klebsiella pneumoniae.
Jayol, Aurélie; Nordmann, Patrice; Desroches, Marine; Decousser, Jean-Winoc; Poirel, Laurent.
Afiliación
  • Jayol A; Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland.
  • Nordmann P; Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland HFR - Hôpital Cantonal, Fribourg, Switzerland.
  • Desroches M; Department of Virology, Bacteriology-Infect Control, Parasitology-Mycology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, Créteil, France IAME, UMR 1137, INSERM, Paris, France.
  • Decousser JW; Department of Virology, Bacteriology-Infect Control, Parasitology-Mycology, Assistance Publique-Hôpitaux de Paris, University Hospital Henri Mondor, Créteil, France IAME, UMR 1137, INSERM, Paris, France.
  • Poirel L; Medical and Molecular Microbiology, Emerging Antibiotic Resistance Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland laurent.poirel@unifr.ch.
Antimicrob Agents Chemother ; 60(5): 3199-201, 2016 05.
Article en En | MEDLINE | ID: mdl-26953194
ABSTRACT
An extended-spectrum ß-lactamase (ESBL)-producing and colistin-resistant Klebsiella pneumoniae clinical isolate was recovered from a patient who was treated with cefotaxime. This isolate harbored a blaCTX-M-15 ESBL gene that was associated with an ISEcp1 insertion sequence. Transposition of that tandem occurred within the chromosomal mgrB gene, leading to inactivation of the mgrB gene and consequently to acquired resistance to colistin. We showed here a coselection of colistin resistance as a result of a broad-spectrum cephalosporin selective pressure.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cefalosporinas / Colistina / Klebsiella pneumoniae / Antibacterianos Idioma: En Año: 2016 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cefalosporinas / Colistina / Klebsiella pneumoniae / Antibacterianos Idioma: En Año: 2016 Tipo del documento: Article