Prophylactic pasireotide administration following pancreatic resection reduces cost while improving outcomes.
J Surg Oncol
; 113(7): 784-8, 2016 Jun.
Article
en En
| MEDLINE
| ID: mdl-27041733
ABSTRACT
BACKGROUND AND OBJECTIVES:
Pasireotide decreases leak rates after pancreatic resection, though significant drug cost may be prohibitive. We conducted a cost-effectiveness analysis to determine whether prophylactic pasireotide possesses a reasonable cost profile.METHODS:
A cost-effectiveness model compared pasireotide administration after pancreatic resection versus usual care, populated by probabilities of clinical outcomes from a randomized trial and hospital costs (2013 US$) from a university pancreatic disease center. Sensitivity analyses were performed to identify influential clinical components of the model.RESULTS:
With the cost of pasireotide included, per patient costs of pancreatectomy, including those for readmission, were lower in the intervention arm (41,769 versus 42,159$; net savings of 390$, or 1%). This was associated with a 56% reduction in pancreatic fistula/pancreatic leak/abscess (PF/PL/A; 21.9-9.2%). Pasireotide cost would need to increase by over 15.4% to make the intervention strategy more costly than usual care. Sensitivity analyses exploring variability of key model inputs demonstrated that the three strongest drivers of cost were (i) cost of pasireotide; (ii) probability of readmission; and (iii) probability of PF/PL/A.CONCLUSIONS:
Prophylactic pasireotide administration following pancreatectomy is cost savings, reducing expensive post-operative sequealae (major complications and readmissions). Pasireotide should be utilized as a cost-saving measure in pancreatic resection. J. Surg. Oncol. 2016;113784-788. © 2016 Wiley Periodicals, Inc.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pancreatectomía
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Complicaciones Posoperatorias
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Somatostatina
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Análisis Costo-Beneficio
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Costos de Hospital
/
Hormonas
Tipo de estudio:
Clinical_trials
/
Etiology_studies
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Health_economic_evaluation
/
Prognostic_studies
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Año:
2016
Tipo del documento:
Article