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Characterization of piRNAs across postnatal development in mouse brain.
Ghosheh, Yanal; Seridi, Loqmane; Ryu, Taewoo; Takahashi, Hazuki; Orlando, Valerio; Carninci, Piero; Ravasi, Timothy.
Afiliación
  • Ghosheh Y; Division of Applied Mathematics and Computer Sciences, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.
  • Seridi L; KAUST Environmental Epigenetic Program (KEEP), Division of Biological and Environmental Sciences &Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.
  • Ryu T; Division of Applied Mathematics and Computer Sciences, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.
  • Takahashi H; KAUST Environmental Epigenetic Program (KEEP), Division of Biological and Environmental Sciences &Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.
  • Orlando V; Division of Applied Mathematics and Computer Sciences, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.
  • Carninci P; KAUST Environmental Epigenetic Program (KEEP), Division of Biological and Environmental Sciences &Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.
  • Ravasi T; RIKEN Center for Life Science Technologies, Division of Genomic Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Sci Rep ; 6: 25039, 2016 04 26.
Article en En | MEDLINE | ID: mdl-27112104
ABSTRACT
PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues- where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encéfalo / Análisis de Secuencia de ARN / ARN Interferente Pequeño / Secuenciación de Nucleótidos de Alto Rendimiento Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encéfalo / Análisis de Secuencia de ARN / ARN Interferente Pequeño / Secuenciación de Nucleótidos de Alto Rendimiento Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article