Feedback Amplification of Neutrophil Function.
Trends Immunol
; 37(6): 412-424, 2016 06.
Article
en En
| MEDLINE
| ID: mdl-27157638
ABSTRACT
As the first line of innate immune defense, neutrophils need to mount a rapid and robust antimicrobial response. Recent studies implicate various positive feedback amplification processes in achieving that goal. Feedback amplification ensures effective migration of neutrophils in shallow chemotactic gradients, multiple waves of neutrophil recruitment to the site of inflammation, and the augmentation of various effector functions of the cells. We review here such positive feedback loops including intracellular and autocrine processes, paracrine effects mediated by lipid (LTB4), chemokine, and cytokine mediators, and bidirectional interactions with the complement system and with other immune and non-immune cells. These amplification mechanisms are not only involved in antimicrobial immunity but also contribute to neutrophil-mediated tissue damage under pathological conditions.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Comunicación Celular
/
Activación Neutrófila
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Retroalimentación Fisiológica
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Inmunidad Innata
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Infecciones
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Inflamación
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Neutrófilos
Límite:
Animals
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article