An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide.

Hu, Kuan; Geng, Hao; Zhang, Qingzhou; Liu, Qisong; Xie, Mingsheng; Sun, Chengjie; Li, Wenjun; Lin, Huacan; Jiang, Fan; Wang, Tao; Wu, Yun-Dong; Li, Zigang

Hu, Kuan; Geng, Hao; Zhang, Qingzhou; Liu, Qisong; Xie, Mingsheng; Sun, Chengjie; Li, Wenjun; Lin, Huacan; Jiang, Fan; Wang, Tao; Wu, Yun-Dong; Li, Zigang.

Afiliación

Hu K; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Geng H; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Zhang Q; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Liu Q; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Xie M; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Sun C; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Li W; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Lin H; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Jiang F; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
Wang T; Department of Biology, Southern University of Science and Technology, Shenzhen, 518055, China. wangtao@sustc.edu.cn.
Wu YD; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. wuyd@pkusz.edu.cn.
Li Z; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.

Angew Chem Int Ed Engl ; 55(28): 8013-7, 2016 07 04.

Article en En | MEDLINE | ID: mdl-27167181

Asunto(s)

Péptidos/química; Péptidos/metabolismo; Secuencia de Aminoácidos; Sitios de Unión; Permeabilidad de la Membrana Celular; Dicroismo Circular; Cristalografía por Rayos X; Receptor alfa de Estrógeno/metabolismo; Células HEK293; Humanos; Ligandos; Espectroscopía de Resonancia Magnética; Modelos Moleculares; Péptidos/farmacología; Permeabilidad; Estructura Secundaria de Proteína; Proteínas Proto-Oncogénicas c-mdm2/metabolismo; Estereoisomerismo

Palabras clave

cell permeability; chirality; helicity; stapled peptide; target binding affinity

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article