Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease.
J Enzyme Inhib Med Chem
; 31(sup2): 194-200, 2016.
Article
en En
| MEDLINE
| ID: mdl-27241372
ABSTRACT
The mosquito-borne West Nile virus (WNV) causes a wide range of symptoms ranging from fever to the often fatal viral encephalitis. To date, no vaccine or drug therapy is available. The trypsin-like WNV NS2B-NS3 protease is deemed a plausible drug target and was shown to be inhibited by bovine pancreatic trypsin inhibitor (BPTI), a 58-residue protein isolated from bovine lung. Herein, we report a protein truncation study that resulted in a novel 14-residue cyclic peptide with equipotent inhibitory activity to native BPTI. We believe our truncation strategy can be further applied in the development of peptide-based inhibitors targeting trypsin-like proteases.
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Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de Proteasas
/
Virus del Nilo Occidental
/
Inhibidores de Tripsina
/
Proteínas no Estructurales Virales
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article