Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation.

Weider, Elodie; Susan-Resiga, Delia; Essalmani, Rachid; Hamelin, Josée; Asselin, Marie-Claude; Nimesh, Surendra; Ashraf, Yahya; Wycoff, Keith L; Zhang, Jianbing; Prat, Annik; Seidah, Nabil G

Weider, Elodie; Susan-Resiga, Delia; Essalmani, Rachid; Hamelin, Josée; Asselin, Marie-Claude; Nimesh, Surendra; Ashraf, Yahya; Wycoff, Keith L; Zhang, Jianbing; Prat, Annik; Seidah, Nabil G.

Afiliación

Weider E; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada.
Susan-Resiga D; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada.
Essalmani R; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada.
Hamelin J; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada.
Asselin MC; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada.
Nimesh S; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada.
Ashraf Y; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada.
Wycoff KL; Planet Biotechnology Inc., Hayward, California 94545-2740, and.
Zhang J; the Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada.
Prat A; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada.
Seidah NG; From the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec H2W 1R7, Canada, seidahn@ircm.qc.ca.

J Biol Chem ; 291(32): 16659-71, 2016 08 05.

Article en En | MEDLINE | ID: mdl-27284008

Asunto(s)

LDL-Colesterol/metabolismo; Proproteína Convertasa 9/metabolismo; Proteolisis/efectos de los fármacos; Receptores de LDL/metabolismo; Anticuerpos de Dominio Único/farmacología; Animales; LDL-Colesterol/genética; Células HEK293; Humanos; Ratones; Ratones Noqueados; Inhibidores de PCSK9; Proproteína Convertasa 9/genética; Receptores de LDL/genética

Palabras clave

Familial Hypercholesterolemia; LDL Receptor; cholesterol regulation; cysteine-histidine-rich-domain (CHRD); inhibitor; low-density lipoprotein (LDL); proprotein convertase subtilisin/kexin type 9 (PCSK9); single-domain antibody (sdAb,nanobody)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de LDL / Proteolisis / Anticuerpos de Dominio Único / Proproteína Convertasa 9 / LDL-Colesterol Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article

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