Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection.
Antimicrob Agents Chemother
; 60(9): 5592-4, 2016 09.
Article
en En
| MEDLINE
| ID: mdl-27324777
ABSTRACT
There is an urgent need for new antibiotics to treat multidrug-resistant Neisseria gonorrhoeae In this report, the microbiology, in vivo pharmacokinetics, and efficacy of REDX05931, a representative novel tricyclic topoisomerase inhibitor, were evaluated. REDX05931 demonstrated high oral bioavailability in mice and reduced N. gonorrhoeae infection after a single dose in a mouse model of gonorrhea. These data support the potential of this series of small molecules as a new treatment for drug-resistant gonorrheal infections.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Gonorrea
/
Inhibidores de Topoisomerasa
/
Antibacterianos
/
Neisseria gonorrhoeae
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article