The Cytoophidium and Its Kind: Filamentation and Compartmentation of Metabolic Enzymes.
Annu Rev Cell Dev Biol
; 32: 349-372, 2016 10 06.
Article
en En
| MEDLINE
| ID: mdl-27362644
ABSTRACT
Compartmentation is essential for the localization of biological processes within a cell. In 2010, three groups independently reported that cytidine triphosphate synthase (CTPS), a metabolic enzyme for de novo synthesis of the nucleotide CTP, is compartmentalized in cytoophidia (Greek for "cellular snakes") in bacteria, yeast, and fruit flies. Subsequent studies demonstrate that CTPS can also form filaments in human cells. Thus, the cytoophidium represents a new type of intracellular compartment that is strikingly conserved across prokaryotes and eukaryotes. Multiple lines of evidence have recently suggested that polymerization of metabolic enzymes such as CTPS and inosine monophosphate dehydrogenase into filamentous cytoophidia modulates enzymatic activity. With many more metabolic enzymes found to form the cytoophidium and its kind, compartmentation via filamentation may serve as a general mechanism for the regulation of metabolism.
Palabras clave
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Compartimento Celular
/
Enzimas
Límite:
Animals
/
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article