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Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model.
Pasciak, Alexander S; Bourgeois, Austin C; Paxton, Ben E; Nodit, Laurentia; Coan, Patricia N; Kraitchman, Dara; Stinnett, Sandra S; Patel, Vijay M; Fu, Yingli; Adams, Joleen K; Tolbert, M Katherine; Lux, Cassie N; Arepally, Aravind; Bradley, Yong C.
Afiliación
  • Pasciak AS; Departments of Radiology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee; The Johns Hopkins University School of Medicine, Baltimore, MD 21205. Electronic address: alexander.pasciak@gmail.com.
  • Bourgeois AC; Departments of Radiology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee; Department of Radiology, The Medical University of South Carolina, Charleston, South Carolina.
  • Paxton BE; Interventional Radiology, Prescott Radiologists, Prescott, Arizona.
  • Nodit L; Pathology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee.
  • Coan PN; Office of Laboratory Animal Care, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee.
  • Kraitchman D; Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD 21205.
  • Stinnett SS; Department of Biostatistics, Duke University Medical Center, Durham, North Carolina.
  • Patel VM; Pathology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee.
  • Fu Y; Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD 21205.
  • Adams JK; Office of Laboratory Animal Care, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee.
  • Tolbert MK; Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee.
  • Lux CN; Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee.
  • Arepally A; Piedmont Radiology, Atlanta, Georgia; Interventional Radiology, Vanderbilt School of Medicine, Nashville, Tennessee.
  • Bradley YC; Departments of Radiology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee.
J Vasc Interv Radiol ; 27(10): 1509-17, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27492867
ABSTRACT

PURPOSE:

To evaluate feasibility of left gastric artery (LGA) yttrium-90 ((90)Y) radioembolization as potential treatment for obesity in a porcine model. MATERIALS AND

METHODS:

This study included 8 young female pigs (12-13 weeks, 21.8-28.1 kg). Six animals received infusions of (90)Y resin microspheres (46.3-105.1 MBq) into the main LGA and the gastric artery arising from the splenic artery. Animal weight and serum ghrelin were measured before treatment and weekly thereafter. Animals were euthanized 69-74 days after treatment, and histologic analyses of mucosal integrity and ghrelin immunoreactive cell density were performed.

RESULTS:

Superficial mucosal ulcerations < 3.0 cm(2) were noted in 5 of 6 treated animals. Ghrelin immunoreactive cell density was significantly lower in treated versus untreated animals in the stomach fundus (13.5 vs 34.8, P < .05) and stomach body (11.2 vs 19.8, P < .05). Treated animals gained less weight than untreated animals over the study duration (40.2 kg ± 5.4 vs 54.7 kg ± 6.5, P = .053). Average fundic parietal area (165 cm(2) vs 282 cm(2), P = .067) and average stomach weight (297.2 g vs 397.0 g, P = .067) were decreased in treated versus untreated animals. Trichrome staining revealed significantly more fibrosis in treatment animals compared with control animals (13.0 vs 8.6, P < .05). No significant differences were identified in plasma ghrelin concentrations (P = .24).

CONCLUSIONS:

LGA (90)Y radioembolization is promising as a potential treatment for obesity. A larger preclinical study is needed to evaluate the safety and efficacy of this procedure further.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arterias / Estómago / Radioisótopos de Itrio / Radiofármacos / Embolización Terapéutica / Obesidad Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arterias / Estómago / Radioisótopos de Itrio / Radiofármacos / Embolización Terapéutica / Obesidad Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article