Cannabinoid receptor interacting protein suppresses agonist-driven CB<sub>1</sub> receptor internalization and regulates receptor replenishment in an agonist-biased manner.

Blume, Lawrence C; Leone-Kabler, Sandra; Luessen, Deborah J; Marrs, Glen S; Lyons, Erica; Bass, Caroline E; Chen, Rong; Selley, Dana E; Howlett, Allyn C

Cannabinoid receptor interacting protein suppresses agonist-driven CB₁ receptor internalization and regulates receptor replenishment in an agonist-biased manner.

Blume, Lawrence C; Leone-Kabler, Sandra; Luessen, Deborah J; Marrs, Glen S; Lyons, Erica; Bass, Caroline E; Chen, Rong; Selley, Dana E; Howlett, Allyn C.

Afiliación

Blume LC; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Leone-Kabler S; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Luessen DJ; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Marrs GS; Department of Biology, Wake Forest University, Winston-Salem, North Carolina, USA.
Lyons E; Center for Molecular Signaling, Wake Forest University, Winston-Salem, North Carolina, USA.
Bass CE; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Chen R; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Selley DE; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Howlett AC; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.

J Neurochem ; 139(3): 396-407, 2016 11.

Article en En | MEDLINE | ID: mdl-27513693

Asunto(s)

Proteínas Portadoras/genética; Proteínas Portadoras/metabolismo; Receptor Cannabinoide CB1/agonistas; Receptor Cannabinoide CB1/metabolismo; Animales; Benzoxazinas/farmacología; Línea Celular; Membrana Celular/metabolismo; Ciclohexanoles/farmacología; Endocannabinoides/fisiología; Dosificación de Gen; Técnicas de Silenciamiento del Gen; Ratones; Morfolinas/farmacología; Naftalenos/farmacología; Piperidinas/farmacología; Transporte de Proteínas; Pirazoles/farmacología; ARN Interferente Pequeño; Receptor Cannabinoide CB1/genética; Receptores de Superficie Celular/efectos de los fármacos; Rimonabant; Transducción de Señal/genética

Palabras clave

CB1 cannabinoid receptor; CP55940; WIN55212-2; cannabinoid receptor interacting protein; receptor trafficking; rimonabant

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Portadoras / Receptor Cannabinoide CB1 Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google