Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.

Scott, Daniel C; Rhee, David Y; Duda, David M; Kelsall, Ian R; Olszewski, Jennifer L; Paulo, Joao A; de Jong, Annemieke; Ovaa, Huib; Alpi, Arno F; Harper, J Wade; Schulman, Brenda A

Scott, Daniel C; Rhee, David Y; Duda, David M; Kelsall, Ian R; Olszewski, Jennifer L; Paulo, Joao A; de Jong, Annemieke; Ovaa, Huib; Alpi, Arno F; Harper, J Wade; Schulman, Brenda A.

Afiliación

Scott DC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Rhee DY; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Duda DM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kelsall IR; MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee DD1 5EH, UK.
Olszewski JL; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
de Jong A; Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Ovaa H; Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Department of Chemical Immunology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Alpi AF; MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee DD1 5EH, UK.
Harper JW; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: wade_harper@hms.harvard.edu.
Schulman BA; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: brenda.schulman@stjude.org.

Cell ; 166(5): 1198-1214.e24, 2016 Aug 25.

Article en En | MEDLINE | ID: mdl-27565346

Asunto(s)

Proteínas Portadoras/metabolismo; Ubiquitina-Proteína Ligasas/metabolismo; Ubiquitina/metabolismo; Ubiquitinación; Ubiquitinas/metabolismo; Proteínas Portadoras/genética; Proteínas Cullin/metabolismo; Técnicas de Silenciamiento del Gen; Células HEK293; Humanos; Mutación; Proteína NEDD8; Poliubiquitina/metabolismo; Proteómica; Especificidad por Sustrato; Enzimas Ubiquitina-Conjugadoras/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ubiquitinas / Proteínas Portadoras / Ubiquitina / Ubiquitina-Proteína Ligasas / Ubiquitinación Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article

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