HPLC studies on the degradation profiles of glucose 5% solutions subjected to heat sterilization in a microprocessor-controlled autoclave.

ABSTRACT

A practically useful relationship between degradation and F0 at various temperatures is given. This may be of value for identifying the most suitable sterilization conditions for a number of glucose products and other pharmaceuticals. It was found that autoclaving at a high temperature to a low final F0 value gave the maximum product integrity.